beijinganbiqishengwukejiyouxiangongsikeyiweikehutigongyizhongnamikangticexufuwu。zheixiangfuwujiyuniaoqiangfayukangtishujukuxiangjiehedejishu“database assisted shotgun sequencing”（dass）suodajiandekangticexupingtai。keyiduikerongxingyugongnengxingnamikangtijinxingvhhjiegouyuxuliequanfugaishidecexu。

namikangti（single domain antibody, sdab），jidanyukangtivhh（variable region of heavy-chain antibody），shiyoubilishikexuejiayu1993nianzaiziranzazhizhongshoucibaodao。yuburudongwuzhongdechuantongkangtibutong，luotuokedongwuzhongdezhongliankangti“heavy-chain antibodies” (hcabs) queshaoyitiaoqinglian（rutu1lvsejiegouyu），kelongqikebianquerdedaodezhiyouyigezhongliankebianquzuchengdedanyukangti，shimuqiankeyidedaodejuyouwanzhenggongnengdewendingdekejiehekangyuandebijiaoxiaodanwei。qixiangduifenzizhiliangwei15kd，jinweichangguikangtide1/10zuoyou，fenzigaodu4.8 nm，zhijing2.2 nm，weinamiji，gubeichengweinamikangti。namikangtijuyouyuchuantongkangtixiangtongdeduimubiaobadiandegaoteyixing、qinhexingyudiduxing。bingqie，yuxiaofenziyaowuleisi，namikangtijuyouchuantongkangtisuoqueshaodededuimeileichanshengyizhi，jinrushoutifengxidenengli。namikangtikeyongyuzhongliudengjibingdezhiliao、jibingdejiance、yimiaodeyanfadeng。

namikangtidewendingxinghao、qinhelijiaogao，kefulexiaofenzigongnengkangtidequedian，tongshiyoujuyoufenzizhiliangxiao、mianyiyuanxingruo、zuzhichuantouliqiangdengdankelongkangti、duokelongkangtibujubeideyoudian，shiyingyushipinjiance、jibingzhiliaodengfangmian。womenkeyigenjukehuxuyao，tigongnamikangticexufuwu。