ADME是药物“吸收（Absorption）、分布（Distribution）、代谢（Metabolism）和外排（Excretion）”的简称，daibiaoleyaowujinrujitihoujitiduiyaowudechuzhiguocheng。yaowudezheisigeshuxingjuedingleyigeyaowuzaitineidenongdu、zuzhifenbuhedaixietujing，duiyuyuceyaowudeshengwuliyongduheshengwuhuoxing（jiyigeyaowunengfoudaodatadezuoyongbadianbingchanshengxiangyingdezhiliaoxiaoguo）juyouzhongyaodecankaojiazhi。yinci，lejiehuahewudeadmetexingduiyuyaowuyanfaguochengyouzhezhongyaodeyiyi。

yaowuyanfashiyigegaofengxian、gaotouru、dantongshiyeshiyigegaohuibaodeguocheng。zaizheiyiguochengzhongyuezaoduiyaowuadmetexingjinxingpingguheyouxuan，yuenengjishipaichudiaoneixieadmetexingbuhaohuahewu，jianshaohouqibubiyaodetouruheziyuandelangfei。anbiqishengwunenggouweinintigongadmejiancefuwu，baokuogaotongliangadmeshaixuan、tiwaiyaowudaixiejiance、yaowushentouxinghezhuanyunshiyandeng。

anbiqishengwuyituoqiduoniandefuwujingyan，keyiweikehutigongyaowuadmetexingjiancefuwu，bingnenggougenjukehujutixuqiushejishiyanfangan，zhulinindeyaowuyanfaguocheng。

高通量ADME筛选

zuoweiyigezaoqiyaoshaidegongju，gaotongliangjishuyijingguangfandiyunyongyuxiandaohuahewudefaxianheyouhuaguochengzhong，bingshishaixuandapilianghuahewuchengweikeneng。womendegaotongliangadmeshaixuanfuwukeyizhenduikehudejutiyaoqiujinxinggexinghuadiaozheng，yimanzubutongkehudexiangmuxuqiu。

ADME筛选过程主要包括以下5个步骤：
• 待筛选药物孔板点样
• MS/MS方法优化
• ADME检测和样品清除
• LC-MS/MS原始数据收集和处理
• 分析后数据的归档
我们的高通量ADME服务可包括以下检测内容：
• 水溶性（热力学&动力学）
• 代谢稳定性（微粒体稳定性、血浆稳定性、肝细胞稳定性等）
• 渗透性（PAMPA）
• 蛋白质结合（血浆、微粒体、脑组织）
• CYP抑制
• CYP 分析
体外药物代谢检测

yaowudeanquanxingheyouxiaoxingshiyaowuyanfaguochengzhongbijiaozhongyaodelianggefangmian，erzheiliangzhezaihendachengdushangdouhuishoudaoyaowudaixietujingheyaowuzhijianxianghuzuoyongdeyingxiang。youyuyaowujinrujitihoutongchanghuibeidaixieweiyigehuozheduogehuoxingzengqianghuozhejianruodedaixiechanwu，yinciyaowudedaixiesulv、daixiechanwudeshengwuhuoxingjiqingchuguochengdouhuizhijieyingxiangdaoyaowuyihuoxingxingshizaijitineidecunliushijian，jineryingxiangdaoxueyaonongdubingkenengyinqiduxingfanying。ciwaiyaowuyuyaowudaixiemeizhijiandexianghuzuoyongyehuiyingxiangdaoqitayaowudedaixiesulvhezaijitineidecunliushijian。yinci，lejieyaowudedaixietujingduiyugenghaodiyuceyaowuduxinghuofuzuoyongyijiyaowuzhijianxianghuzuoyongyouzhongyaodeyiyi，tongshizheixiexinxiyekeyiweijiyaofangandezhiding（baokuohebingyongyao）tigongyidingdezhidao。

药物代谢检测的主要目的包括：
• 明确药物的主要代谢途径及其代谢酶
• 评估被测药物对其它药物代谢过程的影响，反之亦然
我们可提供体外代谢检测服务，包括但不限于：
• 肝细胞稳定性检测
• S9稳定性检测
• 微粒体稳定性检测
• 血浆稳定性检测
• 代谢产物鉴定
• 代谢途径鉴定
• CYP/UGT 反应试验
• CYP 诱导试验
• CYP抑制试验（单点抑制，时间依赖性抑制）
• UGT抑制试验（及其它非CYP代谢酶）
药物渗透性和转运实验

yaowuchuanguoshengwumodenenglishiyingxiangyaowuchuanguoxiaohuadaonianmobeixishouruxuebingtongguoxueyejinrugegezuzhiqiguandeyigezhongyaoyinsu。yaowushentouxingchahuidaozhiyaowudebuliangxishouhuozheyingxiangqizaitineidefenbu。yaowudechuanmonenglizhuyaoshoubeidongkuosanhezhudongyunshulianggefangmiandeyingxiang。

安必奇生物可以提供多种药物渗透性和转运实验，包括：
• Caco-2 渗透转运实验（单向或双向）
• MDCK/MDR1-MDCK渗透性实验
• 人造膜通透性实验（PAMPA）
• 转运实验（P-gp，BCRP，BSEP，OAT1，OAT3，OATP1B1，OATP1B3，OCT1，OCT2等可选）
询价及订购

ganxieninxuanzewogongsideadmejiyaodaidonglixuejiancefuwu。ruyouxiangguandewenti，qingninlianxiwomendegongzuorenyuan，womenjinkuaiweininjiedahefuwu。