youyutongyuanzhongzuxiufuyufeitongyuanmoduanlianjiexiangbifashengpinlvjiaodi，suoyikexuejiakaifaleyongyudanjianjibianjidexitong。gaidanjianjibianjixitongbuxuyaoyoudaodnashuanglianduanlie，yebuxuyaojiarudnaxiufumobanjikeshixianweidiandanjianjidegaibian。gaijishuyichenggongdiyingyongyuduozhongdanziyezhiwuheshuangziyezhiwu，ruxiaomai、shuidao、yumi、ninanjiehefanqiedeng。

crisprdanjianjibianjixitongbaohanyigeshihuodecas9（dead cas9，dcas9）huojinkezaochengquekoudecas9（cas9 nickase，ncas9）hebaogantuoanmeihuoxianpiaolingtuoanmei。baomidingjianjibianjixitong（cytidine base editors，cbes）kejiangbaomiding（c）zhuanbianweiniaomiding（u），niaomidingsuihoutongguodnafuzhihuoxiufudefangshizhuanbianweixiongxianmiding（t）。leisidi，xianpiaolingjianjibianjixitong（adenine base editors，abes）kejiangxianpiaoling（a）zhuanbianweijigan（i），ranhouzhuanbianweiniaopiaoling（g），congershixianadaogdezhuanhuan。

 图1. 具代表性的胞嘧啶（左）和腺嘌呤（右）单碱基编辑系统（Eid et al., 2018）。

公司优势：

• jishushulian，fuwuzhouqiduan、zhilianggao。

• youxuduoxitongkexuan： 

• ketigongduozhongcas9bianti，ruspcas9、sacas9、spvqr-cas9、speqr-cas9、spvrer-cas9hesakkh-cas9，tamenjuyoubutongdepamshibieweidian。

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实验流程：

参考文献

• Eid, A.; et al. (2018).CRISPR base editors: genome editing without double-stranded breaks. Biochemical Journal, 475 (11), 1955-1964.