yixieweishengwubeiyingyongyugongyefajiao，shengchanyichun、shipinjigezhongmeizhijideng。duigongyeweishengwukaizhandejiyinzuyanjiu，buduanfaxianxindeteshumeijiyinjidaixieguochenghedaixiechanwushengchengxiangguandegongnengjiyin，keyijiangqiyingyongyushengchanyijichuantonggongye、gongyidegaizao，tongshituidongxiandaishengwujishudexunsufazhan。
anbiqishengwutuichujiyurectongyuanzhongzufadeweishengwujiyinzugaizaofuwuheliyongcrispr/cas9pingtaideweishengwujiyinzugaizaofuwu。
基于Rec同源重组法的微生物基因组改造服务
xijunjiyinqiaochudechuantongfangfashiliyongzishenderecxitongduiwaiyuanjinrudednajinxingtongyuanzhongzu，congershixianmubiaojiyindedengweitihuan。tongguoshejibajiyindetongyuanronghepianduan，jiangqikelongzhizishazaitizhong，zishazaititongguojieheshurudaobaxijun。tongguokangshengsushaixuanxijunjiyinzubaweidianzhengheyouzishazaitidecharutubianzhu。zaidierlunfanxiangxuanzeyalixia，zhiyouxijunjiyinzufashengdiercitongyuanzhongzubingdiushizishazhilidexijuncaikeyicunhuo。zhihoutongguopcrjiandingjikehuodemudejiyindequeshitubianzhu。
研究对象
gelanshiyinxingxijun，shaobufengelanshiyangxingjun。rudachangganjun、lianmeijun、fenzhiganjun、baisenianzhujundeng。
利用CRISPR/Cas9平台的微生物基因组改造服务[1]
ziranjiezhongdeweishengwuzongshitongguogezhonggeyangdebaohujizhi，shitamennenggouyueliedehuanjingjiqinxixinghesuangongcun。xuduoweishengwudounengtongguojiyujiyinxulieteyixingdefangshidikanghesuanruqin。crispr/cas9jishishuyuzheizhongbaohujizhizhiyi。zaicibeijingxia，anbiqishengwukejituichucrisprfangfajinxingweishengwudejiyinzugaizaofuwu（baokuojiyinqiaochu、dingdiantubian、dingdiancharuwaiyuanxuliedeng）。xiangbiyuchuantongdejiyinqiaochufangfa，gaifangfabianyuhouxudeshiyanyanjiu。
研究对象
dachangganjun、shamenshijun、lianmeijun、suojun、kucaoyabaoganjun、niangjiujiaomu、sizhuangzhenjundeng。
服务优势
• 多基因编辑：能同时敲除多个基因
• 便于筛选：不要求靶细菌具有抗生素抗性
• 定制服务：公司可以代为开发针对该物种的CRISPR基因组编辑系统或利用常规同源重组方法的基因组编辑系统
客户提供信息
• 需改造的菌株及信息
• 靶基因的名称或靶序列
下游应用
• 抗生素及重要工业用酶
• 微生态调节剂参与食品发酵的工业化生产
参考文献：
[1]selle k, barrangou r. harnessing crispr–cas systems for bacterial genome editing[j]. trends in microbiology, 2015, 23(4): 225-232.
询价及订购
ganxieninxuanzewogongsideweishengwujiyinzugaizaofuwu。ruyourenhexiangguandewenti，qingninlianxiwomendegongzuorenyuan，womenjikeweininjiedahefuwu。
