背景介绍

suizherenleishoumingyanzhang，shijierenkoujiegoulaolinghuayulaiyuyanzhong，juguji，quanqiuyueyou4400wanrenhuanyouaercihaimoshizheng（ad）huoxiangguanxingshidechidaizheng，adyanranyichengweixiandaishehuideyidajiankangnanti，duiadjibingdeyanjiuyechengweishijieyixuejiederedian。

adfabingjizhifuza, zhuyaobinglixuetezhengweishenjingxianweichanjie（neurofibrillary tangles,nfts）helaonianban（senile plaques,aps），qizhongnftszhuyaoyoutaudanbaiguodulinsuanhuadaozhi。duoshuxuezherenweiβ-dianfenyangdanbaijilianfanying、taudanbaiguodulinsuanhuashidaozhigaibingfashengfazhandezhuyaoyuanyin。aercihaimobingdezhiliaoyaowuanzhaozuoyongjizhizhuyaoyou4lei：danjianzhimeiyizhiji (acheis) 、feijingzhengxingn-jiaji-d-tiandongansuan (nmda) shoutijiekangji、zuoyongyuaβhetaudanbaideyaowu。jinru21shijiyilai，quanqiugedagongsideyanfaguanxianjihudouweirao“β-dianfenyangdanbaijiashuo”he“taudanbaijiashuo”zheilianggelilunjichujinxingkaifa。

抗Aβ抗体

kangaβkangtinengjinrunaoneiyuβdianfenyangbanjiehe, jihuoaβchenjiwuzhouweidexiaojiaozhixibaotunshiaβchenji, congerjiangdiaβdeshenjingduxing, huanjieaercihaimobingdezhengzhuang。bapizhudankangshijiaozaoyongyuzhiliaoaercihaimobingdedankelongkangti, nengjiangdiqingzhongduaercihaimobinghuanzhenaojiyezhongpizhixianweiaβshuipinghelinsuanhuataudanbaishuiping。jinnianlaiyuelaiyueduozhenduiaβdanbaidedankelongkangtiyaowujinrulinchuangshiyanjieduan, qizhongbaokuolelingtouyangaducanumab，tamenyouwangweiaercihaimobingdezhiliaozhaodaoxindechulu。

Tau蛋白免疫治疗

taudanbaidemianyizhiliaofenweizhudongmianyihebeidongmianyi。zhudongmianyishizhijianghechengdetaudanbaikangyuanzhurujiticongerchanshengtaukangti；beidongmianyishizhijiangtaudanbaikangtizhijiezhurujitinei。cengyanfayaowushitutongguozhudongmianyiliaofacujinguodulinsuanhuadetaudanbaiqingchuyidadaozhiliaoaercihaimobingdemude。

安必奇抗体研究策略

jinnianlaiquanqiukangtiyaowuyanfajinruleyigefazhandeshidai，buduanyoukangtiyaowuluxujinrulinchuangyanjiuheshangshixiaoshou，kangtiyaowuyiranchengweishengwuyaozhongzhongyaozuchengbufen。anbiqidekeyantuanduizhiliyutigongdingzhihuakangtijishufuwutixi，yimanzuguangdakehuduikangtiyaowuyanfadebutongxuqiu。

jiyuzajiaoliu、kangtiwenkuzhanshi（shijuntizhanshi、xijunzhanshihejiaomuzhanshi）dengjishupingtai，anbiqinenggoutigongduowuzhongkangtikaifa（ru tuoyuankangti、 jilgykangti、cangshudankang、 tunshudankang 、 tudankang……），kangtirenyuanhua， kangtiqinhelichengshu， kangtidanbaicexudengduozhongfuwu，zhuanzhuyukangtideshengchanjigongchenglingyu，weinindekangtiyaowuyanfaxiangmubaojiahuhang。

抗体技术平台服务项目

抗体测序
依托质谱技术，提供抗体蛋白测序服务
单克隆抗体制备
基于杂交瘤技术和噬菌体展示技术提供兔、骆驼、人、鲨等多种动物来源的单克隆抗体制备服务
多克隆抗体制备
采用抗原亲和纯化来获得纯化多克隆抗体
膜蛋白抗体制备
针对膜蛋白天然结构抗体的制备技术，避免了传统方法生产膜蛋白单克隆抗体的缺点
抗体药物开发
基于噬菌体展示技术的全人单克隆抗体开发和基于杂交瘤技术的人源化单抗开发，以及相关的亲和力成熟、稳定系构建等服务
ADCC活性检测
caiquyixiliebutongdejiancezhibiaoduibutongdekangtiyaowujinxingadccshengwuxuehuoxingjiancejidingliangfenxi