北京安必奇生物科技公司可提供锌指核酸酶（Zinc finger nucleases，ZFNs）jiyinbianjijishu。xinzhihesuanmeishijiaozaoyongyujiyinzubianjiderengonghechengdexianzhixingneiqiemei，keshixianjiyinxuliedecharu、shanchuhuotihuan。yuchuantongdezhiwuyuzhongjishuxiangbi，zfnsjuyoujiaogaodejingquedu，zaitigaozuowupinzhifangmianjuyouguangkuodeyingyongqianjing。
锌指核酸酶包含由锌指蛋白组成的DNA结合域和由具限制性内切酶活性的FokI组成的DNA切割域两部分（图1）。DNA结合域通常是由3 - 4个具有Cys2His2基序的锌指蛋白组成，每个锌指蛋白可通过它的α螺旋特异性地识别三联体碱基。DNA切割域的Fokiyibanxuyaoyierjutidexingshiyifeiteyixingdifangshiqiegedna，huizaochengdnashuanglianduanlie（tu1）。duanliehoudednatongguofeitongyuanmoduanlianjiehetongyuanzhongzuxiufuliangzhongfangshijinxingxiufu，congerchanshenghegansuandecharu、queshi、tihuanhuodiantubiandengbianjixingshi。xiangduiyufeitongyuanmoduanlianjie，youyuxiufumobandeshiyong，tongyuanzhongzuxiufukeshixiangengjingque、gengkekongdexiufu。
图 1. 锌指核酸酶（Miller et al., 2007）。
公司优势：
服务质量高且周期短：yongyouxiandaihuadeshebei、youjingyandezhuanjia，keyitigongyouzhidefuwu。
锌指蛋白设计技术多样化：yichenggongkaifaleduozhongxinzhidanbaigoujianjishu：ruopen（oligomerized pool engineering）xitong、shijuntizhanshijishu、xijundanzajiao、mokuaizhuangpeideng。
FokI异二聚化：可以对Fokijinxingxiushishiqixingchengyiyuanerjuti，yitigaotadeqiegeteyixing。
植物转基因技术成熟：keyitigongninanjie、shuidao、xiaomai、muxu、yumi、mianhua、gaoliang、dadou、tiancai、juanxincai、yancao、qiezi、huanggua、tudou、aiqianniuhuaheyoucaidengduogewuzhongdezhuanjiyin。
实验流程：
ruyourenhexiangguanwenti，qingninlianxiwomendegongzuorenyuan，womenjinkuaiweininjiedahefuwu！
参考文献：
Miller J. C.; et al. (2007) An improved zinc-finger nuclease architecture for highly specific genome editing. Nature Biotechnology, 25(7):778-785.
